Publications

2016

  • Serban, K.A., et al. Structural and functional characterization of endothelial microparticles released by cigarette smoke. Scientific reports 6, 31596 (2016).
  • Serban, K.A. & Petrache, I. Alpha-1 Antitrypsin and Lung Cell Apoptosis. Annals of the American Thoracic Society 13 Suppl 2, S146-149 (2016).
  • Petrache, I. & Serban, K. Lost in Trans-IL-6 Signaling: Alveolar Type II Cell Death in Emphysema. American journal of respiratory and critical care medicine 194, 1441-1443 (2016).
  • Petrache, I. & Berdyshev, E.V. Ceramide Signaling and Metabolism in Pathophysiological States of the Lung. Annual review of physiology 78, 463-480 (2016).
  • Ni, K., Serban, K.A., Batra, C. & Petrache, I. Alpha-1 Antitrypsin Investigations Using Animal Models of Emphysema. Annals of the American Thoracic Society 13 Suppl 4, S311-316 (2016).
  • Lu, H., et al. Pulmonary Retention of Adipose Stromal Cells Following Intravenous Delivery Is Markedly Altered in the Presence of ARDS. Cell transplantation 25, 1635-1643 (2016).
  • Klionsky, D.J., et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1-222 (2016).
  • Crothers, K., et al. Widespread activation of immunity and pro-inflammatory programs in peripheral blood leukocytes of HIV-infected patients with impaired lung gas exchange. Physiological reports 4(2016).
  • Brown, M.B., et al. High Intensity Interval Training but not Continuous Training Reverses Right Ventricular Hypertrophy and Dysfunction in a Rat Model of Pulmonary Hypertension. American journal of physiology. Regulatory, integrative and comparative physiology, ajpregu.00358.02016 (2016).
  • Brown, M.B., et al. High Intensity Interval Training is Superior to Continuous Training in a Pulmonary Hypertension Rat Model: 751 Board #67 June 1, 3: 30 PM – 5: 00 PM. Medicine and science in sports and exercise 48, 204-205 (2016).

2015

  • Xie, J., et al. Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6. Stem cells (Dayton, Ohio) 33, 468-478 (2015).
  • Schweitzer, K.S., et al. Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures. American journal of physiology. Lung cellular and molecular physiology 309, L175-187 (2015).
  • McCaslin, C.A., et al. Impact of alginate-producing Pseudomonas aeruginosa on alveolar macrophage apoptotic cell clearance. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 14, 70-77 (2015).
  • Lu, H., et al. Conditioned media from adipose stromal cells limit lipopolysaccharide-induced lung injury, endothelial hyperpermeability and apoptosis. Journal of translational medicine 13, 67 (2015).
  • Lockett, A.D., et al. Scavenger receptor class B, type I-mediated uptake of A1AT by pulmonary endothelial cells. American journal of physiology. Lung cellular and molecular physiology 309, L425-434 (2015).
  • Goss, K.N., et al. Neonatal hyperoxic lung injury favorably alters adult right ventricular remodeling response to chronic hypoxia exposure. American journal of physiology. Lung cellular and molecular physiology 308, L797-806 (2015).
  • Christofidou-Solomidou, M., et al. Space radiation-associated lung injury in a murine model. American journal of physiology. Lung cellular and molecular physiology 308, L416-428 (2015).
  • Brown, M.B., et al. Novel assessment of haemodynamic kinetics with acute exercise in a rat model of pulmonary arterial hypertension. Experimental physiology 100, 742-754 (2015).
  • Bowler, R.P., et al. Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes. American journal of respiratory and critical care medicine 191, 275-284 (2015).

2014

  • Zhang, X., et al. Cathepsin E promotes pulmonary emphysema via mitochondrial fission. The American journal of pathology 184, 2730-2741 (2014).
  • Voiles, L., et al. Overexpression of type VI collagen in neoplastic lung tissues. Oncology reports 32, 1897-1904 (2014).
  • Toney, B.M., et al. Selective endothelin-A receptor blockade attenuates endotoxin-induced pulmonary hypertension and pulmonary vascular dysfunction. Pulmonary circulation 4, 300-310 (2014).
  • Petrusca, D.N., et al. Smoking exposure induces human lung endothelial cell adaptation to apoptotic stress. American journal of respiratory cell and molecular biology 50, 513-525 (2014).
  • Petrache, I., Patel, D., Wolf, K.M. & Winer-Muram, H. Vertebral erosion: an uncommon complication of tracheal tubes. American journal of respiratory and critical care medicine 190, e4 (2014).
  • Lockett, A.D., et al. Active trafficking of alpha 1 antitrypsin across the lung endothelium. PloS one 9, e93979 (2014).
  • Lahm, T., Tuder, R.M. & Petrache, I. Progress in solving the sex hormone paradox in pulmonary hypertension. American journal of physiology. Lung cellular and molecular physiology 307, L7-26 (2014).
  • Justice, M.J., et al. Effects of lipid interactions on model vesicle engulfment by alveolar macrophages. Biophysical journal 106, 598-609 (2014).
  • Janes, K., et al. The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. The Journal of biological chemistry 289, 21082-21097 (2014).
  • Hughes, G., et al. MSPrep–summarization, normalization and diagnostics for processing of mass spectrometry-based metabolomic data. Bioinformatics (Oxford, England) 30, 133-134 (2014).
  • Green, L.A., et al. HIV envelope protein gp120-induced apoptosis in lung microvascular endothelial cells by concerted upregulation of EMAP II and its receptor, CXCR3. American journal of physiology. Lung cellular and molecular physiology 306, L372-382 (2014).
  • Cruickshank-Quinn, C.I., et al. Transient and persistent metabolomic changes in plasma following chronic cigarette smoke exposure in a mouse model. PloS one 9, e101855 (2014).
  • Brown, M.B., et al. Loss of cystic fibrosis transmembrane conductance regulator impairs lung endothelial cell barrier function and increases susceptibility to microvascular damage from cigarette smoke. Pulmonary circulation 4, 260-268 (2014).

2013

  • Sahu, R. P. et al. Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists. Journal of immunology (Baltimore, Md. : 1950) 190, 2447-2454, doi:10.4049/jimmunol.1202699 (2013).
  • Petrache, I. & Petrusca, D. N. The involvement of sphingolipids in chronic obstructive pulmonary diseases. Handbook of experimental pharmacology, 247-264, doi:10.1007/978-3-7091-1511-4_12 (2013).
  • Petrache, I. et al. Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models. PloS one 8, e62968, doi:10.1371/journal.pone.0062968 (2013).
  • Lockett, A. D. et al. alpha(1)-Antitrypsin modulates lung endothelial cell inflammatory responses to TNF-alpha. American journal of respiratory cell and molecular biology 49, 143-150, doi:10.1165/rcmb.2012-0515OC (2013).
  • Kamocki, K. et al. RTP801 is required for ceramide-induced cell-specific death in the murine lung. American journal of respiratory cell and molecular biology 48, 87-93, doi:10.1165/rcmb.2012-0254OC (2013).
  • Bardita, C., Predescu, D., Justice, M. J., Petrache, I. & Predescu, S. In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse lungs. Apoptosis : an international journal on programmed cell death 18, 57-76, doi:10.1007/s10495-012-0762-x (2013).

2012

  • Tuder, R. M. & Petrache, I. Pathogenesis of chronic obstructive pulmonary disease. The Journal of clinical investigation 122, 2749-2755, doi:10.1172/jci60324 (2012).
  • Lockett, A. D. et al. Effect of cigarette smoke exposure and structural modifications on the alpha-1 Antitrypsin interaction with caspases. Molecular medicine (Cambridge, Mass.) 18, 445-454, doi:10.2119/molmed.2011.00207 (2012).
  • Lahm, T. & Petrache, I. LC3 as a potential therapeutic target in hypoxia-induced pulmonary hypertension. Autophagy 8, 1146-1147, doi:10.4161/auto.20520 (2012).
  • Lahm, T. et al. 17beta-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects. American journal of respiratory and critical care medicine 185, 965-980, doi:10.1164/rccm.201107-1293OC (2012).
  • Green, L. A. et al. Cigarette smoke-induced CXCR3 receptor up-regulation mediates endothelial apoptosis. American journal of respiratory cell and molecular biology 47, 807-814, doi:10.1165/rcmb.2012-0132OC (2012).

2011

  • Sehra, S. et al. Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. Journal of immunology (Baltimore, Md. : 1950) 186, 4959-4966, doi:10.4049/jimmunol.1002359 (2011).
  • Schweitzer, K. S. et al. Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking. American journal of respiratory and critical care medicine 183, 215-225, doi:10.1164/rccm.201001-0126OC (2011).
  • Schweitzer, K. S. et al. Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides. American journal of physiology. Lung cellular and molecular physiology 301, L836-846, doi:10.1152/ajplung.00385.2010 (2011).
  • Presson, R. G., Jr. et al. Two-photon imaging within the murine thorax without respiratory and cardiac motion artifact. The American journal of pathology 179, 75-82, doi:10.1016/j.ajpath.2011.03.048 (2011).
  • Petrache, I., Petrusca, D. N., Bowler, R. P. & Kamocki, K. Involvement of ceramide in cell death responses in the pulmonary circulation. Proceedings of the American Thoracic Society 8, 492-496, doi:10.1513/pats.201104-034MW (2011).
  • Devlin, C. M. et al. Dihydroceramide-based response to hypoxia. The Journal of biological chemistry 286, 38069-38078, doi:10.1074/jbc.M111.297994 (2011).
  • Clauss, M. et al. Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice. The Journal of clinical investigation 121, 2470-2479, doi:10.1172/jci43881 (2011).

2010

  • Yoshida, T. et al. Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nature medicine 16, 767-773, doi:10.1038/nm.2157 (2010).
  • Tuder, R. M., Janciauskiene, S. M. & Petrache, I. Lung disease associated with alpha1-antitrypsin deficiency. Proceedings of the American Thoracic Society 7, 381-386, doi:10.1513/pats.201002-020AW (2010).
  • Petrusca, D. N. et al. Sphingolipid-mediated inhibition of apoptotic cell clearance by alveolar macrophages. The Journal of biological chemistry 285, 40322-40332, doi:10.1074/jbc.M110.137604 (2010).
  • Diab, K. J. et al. Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema. American journal of respiratory and critical care medicine 181, 344-352, doi:10.1164/rccm.200906-0826OC (2010).

2009

  • Yamada, Y. et al. Type V collagen-induced oral tolerance plus low-dose cyclosporine prevents rejection of MHC class I and II incompatible lung allografts. Journal of immunology (Baltimore, Md. : 1950) 183, 237-245, doi:10.4049/jimmunol.0804028 (2009).
  • Sohrab, S. et al. Mechanism of alpha-1 antitrypsin endocytosis by lung endothelium. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 3149-3158, doi:10.1096/fj.09-129304 (2009).
  • Rajashekhar, G. et al. A monoclonal rat anti-mouse EMAP II antibody that functionally neutralizes pro- and mature-EMAP II in vitro. Journal of immunological methods 350, 22-28, doi:10.1016/j.jim.2009.08.003 (2009).
  • Petrache, I., Hajjar, J. & Campos, M. Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency. Biologics : targets & therapy 3, 193-204 (2009).
  • Noe, J. et al. CFTR regulation of intracellular pH and ceramides is required for lung endothelial cell apoptosis. American journal of respiratory cell and molecular biology 41, 314-323, doi:10.1165/rcmb.2008-0264OC (2009).
  • Ndengele, M. M. et al. Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation. The Journal of pharmacology and experimental therapeutics 329, 64-75, doi:10.1124/jpet.108.146290 (2009).
  • Bryant, L. et al. Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance. Neuroscience letters 463, 49-53, doi:10.1016/j.neulet.2009.07.051 (2009).

2008

  • Petrache, I. et al. Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide. American journal of physiology. Lung cellular and molecular physiology 295, L44-53, doi:10.1152/ajplung.00448.2007 (2008).
  • Petrache, I. et al. HIV associated pulmonary emphysema: a review of the literature and inquiry into its mechanism. Thorax 63, 463-469, doi:10.1136/thx.2007.079111 (2008).
  • Medler, T. R. et al. Apoptotic sphingolipid signaling by ceramides in lung endothelial cells. American journal of respiratory cell and molecular biology 38, 639-646, doi:10.1165/rcmb.2007-0274OC (2008).
  • Iwata, T. et al. Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction. Journal of immunology (Baltimore, Md. : 1950) 181, 5738-5747 (2008).
  • Giordano, R. J. et al. Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse. The Journal of biological chemistry 283, 29447-29460, doi:10.1074/jbc.M804595200 (2008).
  • Cao, L. et al. Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling. Carcinogenesis 29, 1893-1900, doi:10.1093/carcin/bgn158 (2008).

2007

  • Tuder, R. M. & Petrache, I. Molecular multitasking in the airspace: alpha1-antitrypsin takes on thrombin and plasmin. American journal of respiratory cell and molecular biology 37, 130-134, doi:10.1165/rcmb.2007-0163TR (2007).

2006

  • Wagner, E. M., Petrache, I., Schofield, B. & Mitzner, W. Pulmonary ischemia induces lung remodeling and angiogenesis. Journal of applied physiology (Bethesda, Md. : 1985) 100, 587-593, doi:10.1152/japplphysiol.00029.2005 (2006).
  • Tuder, R. M., Yoshida, T., Fijalkowka, I., Biswal, S. & Petrache, I. Role of lung maintenance program in the heterogeneity of lung destruction in emphysema. Proceedings of the American Thoracic Society 3, 673-679, doi:10.1513/pats.200605-124SF (2006).
  • Tuder, R. M., Yoshida, T., Arap, W., Pasqualini, R. & Petrache, I. State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective. Proceedings of the American Thoracic Society 3, 503-510, doi:10.1513/pats.200603-054MS (2006).
  • R

  • Petrache, I. et al. A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema. American journal of respiratory and critical care medicine 173, 1222-1228, doi:10.1164/rccm.200512-1842OC (2006).
  • Petrache, I. et al. alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis. The American journal of pathology 169, 1155-1166 (2006).

2005

  • Petrache, I. et al. Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nature medicine 11, 491-498, doi:10.1038/nm1238 (2005).

2004

  • Rangasamy, T. et al. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. The Journal of clinical investigation 114, 1248-1259, doi:10.1172/jci21146 (2004).

2003

  • Tuder, R. M., Petrache, I., Elias, J. A., Voelkel, N. F. & Henson, P. M. Apoptosis and emphysema: the missing link. American journal of respiratory cell and molecular biology 28, 551-554, doi:10.1165/rcmb.F269 (2003).
  • Petrache, I., Crow, M. T., Neuss, M. & Garcia, J. G. Central involvement of Rho family GTPases in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis. Biochemical and biophysical research communications 306, 244-249 (2003).
  • Petrache, I., Birukova, A., Ramirez, S. I., Garcia, J. G. & Verin, A. D. The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability. American journal of respiratory cell and molecular biology 28, 574-581, doi:10.1165/rcmb.2002-0075OC (2003).
  • Petrache, I. et al. Caspase-dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17, 407-416, doi:10.1096/fj.02-0672com (2003).

2001 and before

  • Petrache, I. et al. Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. American journal of physiology. Lung cellular and molecular physiology 280, L1168-1178 (2001).
  • Petrache, I., Otterbein, L. E., Alam, J., Wiegand, G. W. & Choi, A. M. Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblasts. American journal of physiology. Lung cellular and molecular physiology 278, L312-319 (2000).
  • Petrache, I. et al. Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells. The American journal of physiology 277, L589-595 (1999).
  • Otterbein, L. E. et al. Protective effects of heme oxygenase-1 in acute lung injury. Chest 116, 61S-63S (1999).
  • Chin, B. Y., Petrache, I., Choi, A. M. & Choi, M. E. Transforming growth factor beta1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages. The Journal of biological chemistry 274, 11362-11368 (1999).
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